While Vaccine recreates the look and feel of classic survival horror games, its own additions to that formula leave a lot to be desired. Randomized games can be fun when done right and properly balanced, but Vaccine has no qualms about sometimes generating a game layout that's completely unfair and almost unwinnable, while at other times showering you with more guns and ammo than you know what to do with. If the randomizer was more balanced and perhaps the timer or the multiple playthrough requirement for the true ending were removed, Vaccine could very well be an excellent throwback to the games that started it all - as it stands, however, it's a never-ending exercise in frustration.