During a shooting in court young prostitute Scarlet manages to flee. In a state of confusion, the black Tracy, who was arrested for a minor delict, follows her. When she decides to leave Scarlett, an accident makes it impossible. So they're bound together on a flight from the police and some of the meanest criminals of New York.

Big and Little Enos are opening a sea food restaurant. They bet Sheriff Buford T. Justice that he cannot drive from Miami to the Enos ranch in Texas in a given amount of time. If Buford loses he has to give up his badge.

Harmon (Steven Seagal) is a CIA/DEA enforcer investigating Arab terrorists captured in Mexico. With his team—seductive FBI agent Zara (Jemma Dallender) and spy-drone pilot Sharp (Russell Wong)—he flies to Istanbul and uncovers a brutal plot: Islamic extremists plan to use Sonora drug-smuggling routes to bring deadly weapons, and leaders, into the U.S. To prevent an attack on America, Harmon must turn these two savage forces against one another before his time—and his luck—run out.